Activity of the Novel Extended-spectrum β-Lactamase Inhibitor AAI101 in Combination with Cefepime Towards a Challenge Panel of Acinetobacter baumannii

نویسندگان

  • Ian Morrissey
  • Sophie Magnet
  • Stephen Hawser
  • Stuart Shapiro
  • Harald Seifert
  • Paul Higgins
چکیده

1197. Frequency of Antimicrobial Resistance in Shiga Toxin-Producing Escherichia coli (STEC) and Non-Typhoidal Salmonella (NTS) Clinical Infections and Association with Epidemiological Factors Sanjana Mukherjee, MS; Rebekah Mosci, MS; Chase Anderson, -; Brian Snyder, BS; James Collins, MPH, RS; James Rudrik, PhD and Shannon D. Manning, PhD; Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, Michigan State University, East Lansing, Michigan, Michigan Department of Health and Human Services, Lansing, Michigan, Michigan Department of Community Health, Lansing, Michigan, Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

In Vitro Activity of Cefepime/AAI101 and Comparators against Cefepime Non-susceptible Enterobacteriaceae

We evaluated the in vitro potency of cefepime combined with AAI101, a novel extended-spectrum β-lactamase inhibitor, against a population of clinical Escherichia coli and Klebsiella pneumoniae collected from USA hospitals. Of the 223 cefepime non-susceptible isolates, 95% were ceftazidime non-susceptible, 49% ertapenem non-susceptible, 57% piperacillin/tazobactam non-susceptible, 90% were multi...

متن کامل

In vivo activities of simulated human doses of cefepime and cefepime-AAI101 against multidrug-resistant Gram-negative Enterobacteriaceae.

The combination of cefepime with AAI101, a novel extended-spectrum β-lactamase inhibitor, possesses potent in vitro activity against many resistant Gram-negative pathogens. Against a panel of 20 mostly carbapenemase-producing cefepime-nonsusceptible strains of the family Enterobacteriaceae, we evaluated the MICs of cefepime in the presence of various fixed AAI101 concentrations (1, 2, 4, 8, and...

متن کامل

Characterization, Prevalence and Antibiotic Resistance of Acinetobacter baumannii Infecting Foodstuff

Background: Acinetobacter baumannii is a highly virulent bacterium. It causes opportunistic and nosocomial infections and is a threat to healthcare settings. It has also developed multidrug resistance (MDR) capacity. The nosocomial bacteria and antibiotic resistance are primordial and a significant public health concern. These bacteria and their threat can be prevented by reducing infected food...

متن کامل

Prevalence of Extended Spectrum Beta Lactamases (ESBLs) and Antibiotic Resistance Pattern Acinetobacter Baumannii Strains Isolated from Clinical Specimens in Isfahan City, Iran

Abstract Background and Objective: Acinetobacter species are opportunistic important pathogens responsible for many nosocomial infections. The purpose of this study was to determine the drug resistan pattern Acinetobacter baumannii and prevalence of ESBL producing strains in Intensive Care Unit patients in Isfahan city hospitals. Material and Methods: The study was conducted on 100 Ac...

متن کامل

Extended-spectrum cephalosporinase in Acinetobacter baumannii.

An AmpC-type beta-lactamase conferring high-level resistance to expanded-spectrum cephalosporins and monobactams was characterized from an Acinetobacter baumannii clinical isolate. This class C beta-lactamase (named ADC-33) possessed a Pro210Arg substitution together with a duplication of an Ala residue at position 215 (inside the Omega-loop) compared to a reference AmpC cephalosporinase from A...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 4  شماره 

صفحات  -

تاریخ انتشار 2017